When police went looking for the suspected driver at a house in Craigmore on Saturday night they found two men fighting, with one holding a knife.

A 32-year-old Salisbury North man told officers he’d stabbed himself. The man later died.

Roughly six hours earlier, a pedestrian was struck by a white Toyota four-wheel drive at Andrews Farm following an alleged domestic disturbance.

A 26-year-old man suffered serious but non-life threatening injuries.

Around 9pm police were told the driver involved was at a home in nearby Craigmore.

Two men could be heard arguing and a 4WD matching the description of the car involved in the collision was parked in the driveway.

Officers say they found the pair involved in an altercation on the living room floor and disarmed the 32-year-old.

Police say he was then handcuffed and taken outside.

“Sadly, once outside the premises that man became unresponsive,” Inspector Brett Featherby told reporters on Sunday.

He was given CPR but died before paramedics arrived.

His death is being treated as a death in custody and will be the subject of a report to the State Coroner.

A 41-year-old man involved suffered wounds to his hands and is being treated in hospital.

Police would not reveal details about the dead man as they were still notifying next of kin.

“I’m not going to provide any information about other instances that this man may have been involved in because I can’t for the dignity of himself and his family,” Inspector Featherby said.

Police are now probing whether the Toyota involved in the hit-run was stolen.

The car bears the number plate WWJ 662, but that registration does not match the vehicle.

“We’re actually trying to identify where those number plates are from and when they were obtained,” he said.

Major Crime and Ethical and Professional Standards branch will investigate both incidents.

“There’ll be an independent and full and comprehensive investigation into that incident and the earlier hit-run to identify the links between the two.”

-AAP