Kyrgios’s long-time physio Will Maher says the 2022 Wimbledon runner-up has a cyst growing on his meniscus.

While it’s not a career-threatening injury, Kyrgios is not sufficiently fit to contest his home grand slam.

“I’m obviously extremely disappointed,” Kyrgios said.

“Going in as one of the favourites, it’s brutal.”

He had been due to play Russian Roman Safiullan in the first round on Tuesday night.

The 19th seed’s scratching is another hammer blow to the Melbourne Park major, which was already ravaged by superstar withdrawals and retirements.

Women’s titleholder Ash Barty, seven-times champion Serena Williams, her sister Venus, dual winner Naomi Osaka and retired legend Roger Federer are all missing in 2023.

Australia’s highest-ranked woman Ajla Tomljanovic also pulled out on Saturday with a knee injury.

But Kyrgios’s absence is undoubtedly the biggest setback yet for organisers.

Love or loathe the 27-year-old, tennis’s most polarising figure is compelling viewing.

After inspired runs to last year’s Wimbledon final and US Open quarter-finals, Kyrgios had high hopes of breaking his grand slam duck in Melbourne.

“I’m just exhausted from everything. One of the most important tournaments of my career. Hasn’t been easy at all,” he said of the decision to pull out.

– AAP