The victim has since been identified by police as a 43-year-old from Bedford Park in Adelaide’s south.
Police said he had a puncture wound to his chest, but they are still determining the cause of death.
The man was found lying on the footpath on Alabama Avenue, near Prospect Road, about 5:45am by a member of the public who alerted police.
Paramedics and police arrived a short time later.
“Despite the efforts of paramedics, the man was pronounced deceased at the scene,” police said.
Crime scene tape was placed along a section of Alabama Avenue and outside a house on Prospect Road.
Prospect Road was closed to all traffic in both directions this morning between Regency Road and Livingstone Avenue.
Alabama Avenue was closed from Prospect Road as a forensic team examined the scene.
Police were already in attendance when another passer-by, Kilburn resident Elliott Cragg, ran past this morning.
He said he saw what appeared to be blood on the pavement, and said the area had “a bit of a reputation”.
“When I moved to Australia I didn’t think this situation would be happening on my doorstep,” he said.
“It’s not really the start I wanted for the morning but it is what it is.”
Police have urged anyone who saw or heard anything suspicious in Alabama Avenue or nearby overnight to contact Crime Stoppers on 1800 333 000.